By Micaela Reddy, R. S. Yang, Melvin E. Andersen
A definitive, unmarried resource of data on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is changing into more and more vital in human overall healthiness possibility tests and in assisting pharmacodynamic modeling for poisonous responses. geared up through sessions of compounds and modeling reasons so clients can quick entry info, this is often the 1st entire reference of its kind.
This ebook provides an summary of the underlying rules of PBPK version improvement. Then it presents a compendium of PBPK modeling info, together with old improvement, particular modeling demanding situations, and present practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and fragrant Compounds
* Reactive Vapors within the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and similar Compounds
* insecticides and chronic natural Pollutants
* Dioxin and comparable Compounds
* Metals and Inorganic Compounds
* Antineoplastic Agents
* Perinatal Transfer
* Dermal publicity Models
as well as pinpointing particular info, readers can discover various modeling suggestions and purposes. An authoritative reference for toxicologists, ecotoxicologists, threat assessors, regulators, pharmacologists, pharmacists, and graduate scholars in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles info from leaders within the box and discusses destiny instructions for PBPK modeling.